TREND - Tübinger evaluation of Risk factors for Early detection of NeuroDegeneration 


The occurrence of specific symptoms that allow the clinical diagnosis of Parkinson's and Alzheimer's disease is preceded by a long prodromal phase in which the neurodegenerative process leads to substantial neuronal loss. To enable earlier intervention or even neuroprotective therapy it is essential to identify, characterize and validate risk and prodromal markers for Parkinson’s and Alzheimer’s disease.

Approx. 1200 individuals with a specific risk profile aged over 50 years at baseline are biennial assessed by a comprehensive, quantitative assessment battery to meet these aims. The TREND study has been initiated in 2009 and after its 10 year anniversary collects data in the sixth wave of the prospective study.