Autonomic symptoms in older adults are common and associated with health-related quality of life

Renno-Busch S, Hildesheim H, van Uem JMT, Sünkel U, Röben B, Brockmann K, Mychajliw C, Eschweiler GW, Berg D, Maetzler W

Frontiers in Neurology November 2021, Volume 12, Article 757748

 

Arm swing responsiveness to dopamindergic medication in Parkinson's diesease depends on task complexity

Warmerdam E, Rmijnders R, Hansen C, Elshehabi M, Zimmermann M, Metzger FG, von Thaler A-K, Berg D, Schmidt G, Maetzler W

npj Parkinson's Disease (2021)7:89

 

Comparing the Two Prodromal Parkinson's Disease Research Criteria - Lessons for Future Studies

Yilmaz R, Sünkel U, The TREND Study Team, Postuma R, Heinzel S, Berg D

Movement Disorders, 2021 Apr 30

 

Impaired executive function an depression as independent risk factors for reported delirium symptoms: an observational cohort study over 8 years

Mychajliw C, Herrmann ML, Sünkel U, Brand K, von Thaler A-K, Wurster I, Yimaz R, Eschweiler GW, Metzger F

Front. Aging Neurosci. in press, 2021 Apr

 

Abnormally Reduced Frontal Cortex Activity During Trail Making Test in Prodromal Parkinson's Disease - A fNIRS Study

Hofmann A, Rosenbaum D, Int-Veen I, Ehlis A-C, Brockmann K, Dehnen K, von Thaler A-K, Berg D, Fallgatter AJ, Metzger F

Neurobiology of Aging, in press, 2021 Apr 28

 

Age-related deterioration of performance and increase of cortex activity comparing time-versus item-controlled fNIRS measurement

Blum L, Rosenbaum D, Röben B, Dehnen K, Maetzler W, Sünkel U, Fallgatter AJ, Ehlis A-C, Metzger F

Sci Rep 2021 Mar 24;11 (1):6766

 

Insulin sensitivity predicts cognitive decline in individuals with prediabetes

Willmann C, Brockmann K, Wagner R, Kullmann S, Preissl H, Schnauder G, Maetzler W, Gasser T, Berg D, Eschweiler GW, Metzger F, Fallgatter AJ, Häring H-U, Fritsche A, Heni M

BMJ Open Diab Res Care 2020;8

 

Common diseases alter the physiological age-related blood microRNA profile

Fehlmann T, Lehallier B, Schaum N. Hahn O. Kahraman M. Li Y, Grammes N, Geffers L, Backes C. Balling R, Kern F, Krüger R, Lammert F, Ludwig N, Meder B, Fromm B, Maetzler W, Berg D, Brockmann K, Deuschle C, von Thaler A-K, Eschweiler G, Reichert M, Wyss-Coray T, Meese E, Keller A, Barzilai N, Milman S

Nature Communications (2020)11:5958

 

The effect of age and gender on anti-saccade performance: Results from a large cohort of healthy aging individuals

Mack DJ, Heinzel S, Pilotto A, Stetz L, Lachenmaier S, Guggolz L, Srulijes K, Eschweiler GW, Sünkel U, Berg D, Ilg UJ

Eur J Neurosci. 2020;00: 1-20.

 

Gut microbiome signature of risk and prodromal markers of Parkinson's disease

Heinzel S, Aho VTE, Suenkel U, von Thaler A-K, Schulte C, Deuschle C, Paulin L, Hantunen S, Brockmann K, Eschweiler GW, Maetzler W, Berg D, Auvinen P, Scheperjans F

Annals of Neurology 2020;00:1-12

 

Intraindividual neurofilament dynamics in serum mark the conversion to sporadic Parkinson's disease

Wilke C, dos Santos M, Schulte C, Deuschle C, Scheller D, Verelen M, Brockmann K, von Thaler A-K, Suenkel U, Roeben B, Bujac S, Metzger F, Maetzler W, da Costa A, Synofzik M, Berg D.

Movement Disorders, 2020 Apr 27

 

Evaluation the use of Circulating MicroRNA Profiles for Lung Cancer Dtection in Symptomatic Patients

Fehlmann T, Kahraman M, Ludwig N, Backes C, Galata V, Keller V, Geffers L, Mercaldo N, Hornung D, Weis T, Kayvanpour E, Abu-Halima M, Deuschle C, Schulte C, Suenkel U, von Thaler A-K, Maetzler W, Herr C, Fähndrich S, Vogelmeier C, Guimaraes P, Hecksteden A, Meyer T, Metzger F, Diener C, Deutscher S, Abdul-Khaliq H, Stehle I, Haeusler S, Meiser A, Groesdonk HV, Volk T, Lenhof H-P, Katus H, Balling R, Meder B, Krueger R, Huwer H, Bals R, Meese E, Keller A

JAMA Onc,  published online March 5, 2020. doi:10.1001/jamaoncol.2020.0001

 

 

Machine learning to detect Alzheimer's diesease from circulating non-coding RNAs

Ludwig N, Fehlmann T, Kern F, Gogol M, Maetzler W, Deutscher S, Gurlit S, Schulte C, von Thaler A-K, Deuschle C, Metzger F, Berg D, Suenkel U, Keller V, Backes C, Lenhof H-P, Meese E, Keller A

Genomics, Proteomics Bioinformatics  17 (2019) 430-440

 

Gait Analysis with Wearables Predicts Conversion to Parkinson Disease

Del Din S, Elshehabi M, Galna B, Hobert MA, Warmerdam E, Suenkel U, Brockmann K, Metzger F, Hansen C, Berg D, Rochester L, Maetzler W

Ann Neurol 2019;86:357-367

 

Orthostatic hypotension as a risk factor for longitudinal detoriation of cognitive function in elderly

Zimmermann M, Wurster I, Lerche S, Roeben B, Machetanz G, Suenkel U, von Thaler A-K, Eschweiler G, Fallgatter A, Maetzler W, Berg D, Brockmann K

European Journal of Neurology. 2020 Jan; 27(1):160-167. doi:10.1111/ene.14050.Epub 2019 Aug 26

  

Prodromal features of Parkinson's disease: Self-reported symptoms versus clinically assessed signs

Friederich A, Flinspach A, Suenkel U, Eschweiler GW, Greulich K, TREND study team, Maetzler W, Berg D,

Heinzel S

Mov Disord. 2019 Jan;34(1):144-146

 

REM sleep behaviour disorder (RBD): risk for Parkinsonism and executive dysfunction in elderly

Stefanie Lerche and Kathrin Brockmann

Oncotarget, 2018, Vol. 9, (No. 95), pp: 36732-36733

 

Cholinergic Pathway SNPs and Postural Control in 477 Older Adults

Arnold C, Schulte C, Moscovich M, Sünkel U, Zaunbrecher L, Metzger F, Gasser T, Eschweiler GW, Hauser A-K, Berg D, Maetzler W

Front. Aging Neurosci. 10:260 Sep 2018

 

Arm swing asymmetry in overground walking

Killeen T, Elshehabi M, Filli L, Hobert MA, Hansen C, Rieger D, Brockmann K, Nussbaum S, Zörner B, Bolliger M, Curt A, Berg D, Maetzler W

Sci Rep. 2018 Aug 24;8(1):12803

 

Deterioration of executive dysfunction in elderly with REM sleep behavior disorder (RBD)

Lerche S, Machetanz G, Roeben B, Wurster I, Zimmermann M, von Thaler A-K, Liepelt-Scarfone I, Eschweiler G, Fallgatter A, Metzger F, Maetzler W, Berg D, Brockmann K

Neurobiology of Aging 70 (2018) 242-246.

 

Effect of physical activity on cognitive flexibility, depression and RBD in healthy elderly.

Lerche S, Gutfreund A, Brockmann K, Hobert MA, Wurster I, Suenkel U, Eschweiler GW, Metzger FG, Maetzler W, Berg D

Clin Neurol Neurosurg. 2018 Jan 9; 165: 88-93.

 

Gait is associated with cognitive flexibility: A dual-tasking study in healthy older people

Hobert MA, Meyer SI, Hasmann SE,  Metzger FG, Suenkel U, Eschweiler GW, Berg D, Maetzler W

Front. Aging Neurosci. May 2017;9,:154.

 

Structural Ultrasound of the Medial Temporal Lobe in Alzheimer's Disease

Yilmaz R, Pilotto A, Roeben B, Preische O, Suenkel U, Heinzel S,  Metzger FG, Laske C, Maetzler W, Berg D

Ultraschall in Med 2017; 38-294-300.

 

Application of the movement disorder society prodromal Parkinson's disease research criteria in 2 indeprendent prospective cohorts.

Pilotto A, Heinzel S, Suenkel U, Lerche S, Brockmann K, Roeben B, Schaeffer E, Wurster I, Yilmaz R, Liepelt-Scarfone I, von Thaler A-K, Metzger FG, Eschweiler GW, Postuma RB, Maetzler W, Berg D

Movement Disorders 2017 Jul; 32(7): 1025-1034.

 

Evidence for a Selectively Regulated Prioritization Shift Depending on Walking Situations in Older Adults

Salkovic D, Hober MA, Bellut C, Funer F, Renno S, Haertner L, Hasmann S, Staebler J, Geritz J, Suenkel U, Fallgatter AJ, Eschweiler GW, Berg D, Maetzler W

Front. Aging Neurosci.April 2017;9:75.

 

Associations between early markers of Parkinson's disease and sarcopenia

Drey M, Hasmann SE, Krenovsky J, Hobert MA, Straub S, Elshehabi M, von Thaler A-K, Fallgatter AJ, Eschweiler GW, Suenkel U, Berg D, Maetzler W

Front. Aging Neurosci.March 2017;9:53.

 

Cognitive Performance Patterns in Healthy Individuals with Substantia Nigra Hyperechogenicity and Early Parkindon's Disease

Rezzak Y, Gräber S, Roeben B, Suenkel U, von Thaler A-K, Heinzel S., Methger FG, Eschweiler GW, Maetzler W, Berg D and Liepelt-Scarfone I

Front. Aging Neurosci.November 2016;8:271.

 

Prospective longitudinal course of cognition in older subjects with mild parkinsonian signs.

Lerche S, Brockmann K, Pilotto A, Wurster I, Sünkel U, Hobert MA, von Thaler A-K, Schulte C, Stoops E, Vanderstichele H, Herbst V, Brix B, Eschweiler GW, Metzger FG, Maetzler W, Berg D

Alzheimers Res Ther. 2016 Oct 10;8(1):42.

 

Dual Tasking for the Differentiation between Depression and Mild Cognitive Impairment.

Metzger FG, Hobert MA, Ehlis A-C, Hasmann SE, Hahn T, Eschweiler GW, Berg D, Fallgatter AJ, Maetzler; TREND study team.

Front. Aging Neurosci. 2016 Sep 8:235.

 

Association of Plasma Aβ40 Peptides, But Not Aβ42, with Coronary Artery Disease and Diabetes Mellitus

Roeben B, Maetzler W, Vanmechelen E, Schulte C, Heinzel S, Stellos K, Godau J, Huber H, Brockmann K, Wurster I, Gaenslen A, Grüner E, Niebler R, Eschweiler GW, Berg D; TREND study team.

J Alzheimers Dis. 2016 Mar 16;52(1):161-9.

 

State-dependent altered connectivity in late-life depression: a functional near-infrared spectroscopy study
Rosenbaum D, Hagen K, Deppermann S, Kroczek A M, Haeussinger F B, Heinzel S, Berg D, Fallgatter A J, Metzger F G, Ehlis A-C, the TREND study Consortium.

Neurobiology of Aging 39 (2016)57-68.

Age and Vascular Burden Determinants of Cortical Hemodynamics Underlying Verbal Fluency
Heinzel S, Metzger, FG, Ehlis, A-C, Korell R, Alboji A, Haeussinger F B, Wurster I, Brockmann K, Suenkel U, Eschweiler GW, Maetzler W, Berg D, Fallgatter AJ.

PLoS One. 10(9): e0138863 September 22, 2015.

Reasons for mild parkinsonian signs - which constellation may indicate neurodegeneration?
Lerche S, Brockmann K, Wurster I, Gaenslen A, Roeben B, Holz D, Eschweiler GW, Maetzler W, Berg D. Parkinsonism Relat Disord. 2015 Feb 21 (2):126-30.

The relation of SMI and the VSEP in a risk sample for neurodegenerative disorders
Hagen K, Ehlis AC, Haeussinger FB, Beeretz S, Kromer GV, Heinzel S, Maetzler W, Eschweiler GW, Berg D, Fallgatter AJ, Metzger FG, The TREND Study Consortium.

J Neural Transm. 2014 Dec 18.

Prodromal features for Parkinson's disease - baseline data from the TREND study
Gaenslen A, Wurster I, Brockmann K, Huber H, Godau J, Faust B, Lerche S, Eschweiler GW, Maetzler W, Berg D. Eur J Neurol. 2014 May;21(5):766-72

Mild parkinsonian signs in the elderly - is there an association with PD? Crossectional findings in 992 individuals
Lerche S, Hobert M, Brockmann K, Wurster I, Gaenslen A, Hasmann S, Eschweiler GW, Maetzler W, Berg D.

PLoS One. 2014 9(3):e92878.
link

A neurodegenerative vascular burden index and the impact on cognition
Heinzel S, Liepelt-Scarfone I, Roeben B, Nasi-Kordhishti I, Suenkel U, Wurster I, Brockmann K, Fritsche A, Niebler R, Metzger RG, Eschweiler GW, Fallgatter AJ, Maetzler W, Berg.

Front Aging Neurosci. 2014 Jul 9;6:161
link

Lowered serum amyloid-ß 1-42 autoantibodies in individuals with lifetime depression.
Maetzler W, Langkamp M, Lerche S, Godau J, Brockmann K, Gaenslen A, Huber H, Wurster I, Niebler R, Eschweiler GW, Berg D.

Journal of Alzheimer's Disease 2012 Jul 5

Aging-related cortical reorganization of verbal fluency processing: an NIRS study
Heinzel S, Metzger FG, Ehlis A-C, Korell R, Alboji A, Haeussinger FB, Hagen K, Maetzler W, Eschweiler GW, Berg D, Fallgatter AJ and the TREND study consortium. Neurobiology of Aging 2012 Jul 5

Poor trail making test performance is directly associated with altered dual task prioritization in the elderly-baseline results from the TREND study.
Hobert MA, Niebler R, Meyer SI, Brockmann K, Becker C, Huber H, Gaenslen A, Godau J, Eschweiler GW, Berg D, Maetzler W.

PLoS One. 2011;6(11):e27831
link