Publikationen

2024

 

Kluge, A., Schaeffer, E., Bunk, J., Sommerauer, M., Röttgen, S., Schulte, C., Roeben, B., von Thaler, A., Welzel, J., Lucius, R., Heinzel, S., Xiang, W., Eschweiler, G. W., Maetzler, W., Suenkel, U., & Berg, D. (2024). Detecting Misfolded α‐Synuclein in Blood Years before the Diagnosis of Parkinson’s Disease. Movement Disorders. https://doi.org/10.1002/mds.29766


Roeben, B., Liepelt-Scarfone, I., Lerche, S., Zimmermann, M., Wurster, I., Sünkel, U., Schulte, C., Deuschle, C., Eschweiler, G. W., Maetzler, W., Gasser, T., Berg, D., & Brockmann, K. (2024). Longitudinal cognitive decline characterizes the profile of non-PD-manifest GBA1 mutation carriers. Npj Parkinson’s Disease, 10(1), 88. https://doi.org/10.1038/s41531-024-00706-1

 

2023

Kastner, L., Suenkel, U., Eschweiler, G. W., Dankowski, T., von Thaler, A.-K., Mychajliw, C., Brockmann, K., Maetzler, W., Berg, D., Fallgatter, A. J., Heinzel, S., & Thiel, A. (2023). Older adults’ coping strategies during the COVID-19 pandemic – a longitudinal mixed-methods study. Frontiers in Psychology, 14(September). https://doi.org/10.3389/fpsyg.2023.1209021

 

Dankowski, T., Kastner, L., Suenkel, U., von Thaler, A.-K., Mychajliw, C., Krawczak, M., Maetzler, W., Berg, D., Brockmann, K., Thiel, A., Eschweiler, G. W., & Heinzel, S. (2023). Longitudinal dynamics of depression in risk groups of older individuals during the COVID-19 pandemic. Frontiers in Epidemiology, 3(February), 1–13. https://doi.org/10.3389/fepid.2023.1093780

 

Sood, M., Suenkel, U., von Thaler, A.-K., Zacharias, H. U., Brockmann, K., Eschweiler, G. W., Maetzler, W., Berg, D., Fröhlich, H., & Heinzel, S. (2023). Bayesian network modeling of risk and prodromal markers of Parkinson’s disease. PLOS ONE, 18(2), e0280609. https://doi.org/10.1371/journal.pone.0280609

 

Todd, G., Rae, C. D., Taylor, J. L., Rogasch, N. C., Butler, J. E., Hayes, M., Wilcox, R. A., Gandevia, S. C., Aoun, K., Esterman, A., Lewis, S. J. G., Hall, J. M., Matar, E., Godau, J., Berg, D., Plewnia, C., von Thaler, A., Chiang, C., & Double, K. L. (2023). Motor cortical excitability and pre‐supplementary motor area neurochemistry in healthy adults with substantia nigra hyperechogenicity. Journal of Neuroscience Research, 101(2), 263–277. https://doi.org/10.1002/jnr.25145

 

2022

Blum, L., Hofmann, A., Rosenbaum, D., Elshehabi, M., Suenkel, U., Fallgatter, A. J., Ehlis, A. C., & Metzger, F. G. (2022). Effects of aging on functional connectivity in a neurodegenerative risk cohort: resting state versus task measurement using near-infrared spectroscopy. Scientific Reports, 12(1), 1–11. https://doi.org/10.1038/s41598-022-13326-7

 

Elshehabi, M., Del Din, S., Hobert, M. A., Warmerdam, E., Sünkel, U., Schmitz-Hübsch, T., Behncke, L. M., Heinzel, S., Brockmann, K., Metzger, F. G., Schlenstedt, C., Rochester, L., Hansen, C., Berg, D., & Maetzler, W. (2022). Walking parameters of older adults from a lower back inertial measurement unit, a 6-year longitudinal observational study. Frontiers in Aging Neuroscience, 14(September). https://doi.org/10.3389/fnagi.2022.789220

 

2021

Blum, L., Rosenbaum, D., Röben, B., Dehnen, K., Maetzler, W., Suenkel, U., Fallgatter, A. J., Ehlis, A.-C., & Metzger, F. G. (2021). Age-related deterioration of performance and increase of cortex activity comparing time- versus item-controlled fNIRS measurement. Scientific Reports, 11(1), 6766. https://doi.org/10.1038/s41598-021-85762-w

 

Heinzel, S., Aho, V. T. E., Suenkel, U., Thaler, A., Schulte, C., Deuschle, C., Paulin, L., Hantunen, S., Brockmann, K., Eschweiler, G. W., Maetzler, W., Berg, D., Auvinen, P., & Scheperjans, F. (2021). Gut Microbiome Signatures of Risk and Prodromal Markers of Parkinson Disease. Annals of Neurology, 90(3), E1–E12. https://doi.org/10.1002/ana.26128

 

Hofmann, A., Rosenbaum, D., Int-Veen, I., Ehlis, A., Brockmann, K., Dehnen, K., von Thaler, A.-K., Berg, D., Fallgatter, A. J., & Metzger, F. G. (2021). Abnormally reduced frontal cortex activity during Trail-Making-Test in prodromal parkinson’s disease–a fNIRS study. Neurobiology of Aging, 105, 148–158. https://doi.org/10.1016/j.neurobiolaging.2021.04.014

 

Mychajliw, C., Herrmann, M. L., Suenkel, U., Brand, K., von Thaler, A.-K., Wurster, I., Yilmaz, R., Eschweiler, G. W., & Metzger, F. G. (2021). Impaired Executive Function and Depression as Independent Risk Factors for Reported Delirium Symptoms: An Observational Cohort Study Over 8 Years. Frontiers in Aging Neuroscience, 13. https://doi.org/10.3389/fnagi.2021.676734

 

Renno-Busch, S., Hildesheim, H., van Uem, J. M. T., Sünkel, U., Röben, B., Brockmann, K., Mychajliw, C., Eschweiler, G. W., Berg, D., & Maetzler, W. (2021). Autonomic Symptoms in Older Adults Are Common and Associated With Health-Related Quality of Life. Frontiers in Neurology, 12. https://doi.org/10.3389/fneur.2021.757748

 

Warmerdam, E., Romijnders, R., Hansen, C., Elshehabi, M., Zimmermann, M., Metzger, F. G., von Thaler, A.-K., Berg, D., Schmidt, G., & Maetzler, W. (2021). Arm swing responsiveness to dopaminergic medication in Parkinson’s disease depends on task complexity. Npj Parkinson’s Disease, 7(1), 89. https://doi.org/10.1038/s41531-021-00235-1

 

Yilmaz, Rezzak, Suenkel, U., Postuma, R. B., Heinzel, S., & Berg, D. (2021). Comparing the Two Prodromal Parkinson’s Disease Research Criteria—Lessons for Future Studies. Movement Disorders, 36(7), 1731–1732. https://doi.org/10.1002/mds.28637

 

2020

Alzaid, H., Ethofer, T., Hobert, M. A., Kardatzki, B., Erb, M., Maetzler, W., & Berg, D. (2020). Distinct Relationship Between Cognitive Flexibility and White Matter Integrity in Individuals at Risk of Parkinson’s Disease. Frontiers in Aging Neuroscience, 12(August), 1–10. https://doi.org/10.3389/fnagi.2020.00250

 

Fehlmann, T., Kahraman, M., Ludwig, N., Backes, C., Galata, V., Keller, V., Geffers, L., Mercaldo, N., Hornung, D., Weis, T., Kayvanpour, E., Abu-Halima, M., Deuschle, C., Schulte, C., Suenkel, U., von Thaler, A.-K., Maetzler, W., Herr, C., Fähndrich, S., … Keller, A. (2020). Evaluating the Use of Circulating MicroRNA Profiles for Lung Cancer Detection in Symptomatic Patients. JAMA Oncology, 6(5), 714. https://doi.org/10.1001/jamaoncol.2020.0001

 

Fehlmann, T., Lehallier, B., Schaum, N., Hahn, O., Kahraman, M., Li, Y., Grammes, N., Geffers, L., Backes, C., Balling, R., Kern, F., Krüger, R., Lammert, F., Ludwig, N., Meder, B., Fromm, B., Maetzler, W., Berg, D., Brockmann, K., … Keller, A. (2020). Common diseases alter the physiological age-related blood microRNA profile. Nature Communications, 11(1), 5958. https://doi.org/10.1038/s41467-020-19665-1

 

Mack, D. J., Heinzel, S., Pilotto, A., Stetz, L., Lachenmaier, S., Gugolz, L., Srulijes, K., Eschweiler, G. W., Sünkel, U., Berg, D., & Ilg, U. J. (2020). The effect of age and gender on anti-saccade performance: Results from a large cohort of healthy ageing individuals. The European Journal of Neuroscience, August 2019, 1–20. https://doi.org/10.1111/ejn.14878

 

Wilke, C., Santos, M. C. T., Schulte, C., Deuschle, C., Scheller, D., Verbelen, M., Brockmann, K., Thaler, A., Sünkel, U., Roeben, B., Bujac, S., Metzger, F. G., Maetzler, W., Costa, A. N., Synofzik, M., & Berg, D. (2020). Intraindividual Neurofilament Dynamics in Serum Mark the Conversion to Sporadic Parkinson’s Disease. Movement Disorders, 35(7), 1233–1238. https://doi.org/10.1002/mds.28026

 

Willmann, C., Brockmann, K., Wagner, R., Kullmann, S., Preissl, H., Schnauder, G., Maetzler, W., Gasser, T., Berg, D., Eschweiler, G. W., Metzger, F., Fallgatter, A. J., Häring, H.-U., Fritsche, A., & Heni, M. (2020). Insulin sensitivity predicts cognitive decline in individuals with prediabetes. BMJ Open Diabetes Research & Care, 8(2), e001741. https://doi.org/10.1136/bmjdrc-2020-001741

 

Zimmermann, M., Wurster, I., Lerche, S., Roeben, B., Machetanz, G., Sünkel, U., von Thaler, A. K., Eschweiler, G., Fallgatter, A. J., Maetzler, W., Berg, D., & Brockmann, K. (2020). Orthostatic hypotension as a risk factor for longitudinal deterioration of cognitive function in the elderly. European Journal of Neurology, 27(1), 160–167. https://doi.org/10.1111/ene.14050

 

2019

Del Din, Silvia, Elshehabi, M., Galna, B., Hobert, M. A., Warmerdam, E., Suenkel, U., Brockmann, K., Metzger, F., Hansen, C., Berg, D., Rochester, L., & Maetzler, W. (2019). Gait analysis with wearables predicts conversion to parkinson disease. Annals of Neurology, 86(3), 357–367. https://doi.org/10.1002/ana.25548

 

Friederich, A., Flinspach, A., Suenkel, U., Eschweiler, G. W., Greulich, K., Maetzler, W., Berg, D., Heinzel, S., study team, T., Maetzler, W., Berg, D., & Heinzel, S. (2019). Prodromal features of Parkinson’s disease: Self-reported symptoms versus clinically assessed signs. Movement Disorders, 34(1), 144–146. https://doi.org/10.1002/mds.27539

 

Ludwig, N., Fehlmann, T., Kern, F., Gogol, M., Maetzler, W., Deutscher, S., Gurlit, S., Schulte, C., von Thaler, A.-K., Deuschle, C., Metzger, F., Berg, D., Suenkel, U., Keller, V., Backes, C., Lenhof, H.-P., Meese, E., & Keller, A. (2019). Machine Learning to Detect Alzheimer’s Disease from Circulating Non-coding RNAs. Genomics, Proteomics & Bioinformatics, 17(4), 430–440. https://doi.org/10.1016/j.gpb.2019.09.004

 

2018

Arnold, C., Schulte, C., Moscovich, M., Sünkel, U., Zaunbrecher, A.-L., Metzger, F. G., Gasser, T., Eschweiler, G. W., Hauser, A.-K., Berg, D., & Maetzler, W. (2018). Cholinergic pathway SNPs and postural control in 477 older adults. Frontiers in Aging Neuroscience, 10, 260. https://doi.org/10.3389/FNAGI.2018.00260

 

Heinzel, S., Kasten, M., Behnke, S., Vollstedt, E. J., Klein, C., Hagenah, J., Pausch, C., Heilmann, R., Brockmann, K., Suenkel, U., Yilmaz, R., Liepelt-Scarfone, I., Walter, U., & Berg, D. (2018). Age- and sex-related heterogeneity in prodromal Parkinson’s disease. Movement Disorders, 33(6), 1025–1027. https://doi.org/10.1002/mds.27349

 

Killeen, T., Elshehabi, M., Filli, L., Hobert, M. A., Hansen, C., Rieger, D., Brockmann, K., Nussbaum, S., Zörner, B., Bolliger, M., Curt, A., Berg, D., & Maetzler, W. (2018). Arm swing asymmetry in overground walking. Scientific Reports, 8(1), 1–10. https://doi.org/10.1038/s41598-018-31151-9

 

Lerche, S., & Brockmann, K. (2018). REM sleep behaviour disorder (RBD): risk for Parkinsonism and executive dysfunction in elderly. Oncotarget, 9(95), 36732–36733. https://doi.org/10.18632/oncotarget.26417

 

Lerche, S., Gutfreund, A., Brockmann, K., Hobert, M. A., Wurster, I., Sünkel, U., Eschweiler, G. W., Metzger, F. G., Maetzler, W., & Berg, D. (2018). Effect of physical activity on cognitive flexibility, depression and RBD in healthy elderly. Clinical Neurology and Neurosurgery, 165, 88–93. https://doi.org/10.1016/j.clineuro.2018.01.008

 

Lerche, S., Machetanz, G., Roeben, B., Wurster, I., Zimmermann, M., von Thaler, A.-K., Liepelt-Scarfone, I., Eschweiler, G. W., Fallgatter, A., Metzger, F., Maetzler, W., Berg, D., & Brockmann, K. (2018). Deterioration of executive dysfunction in elderly with REM sleep behavior disorder (RBD). Neurobiology of Aging, 70, 242–246. https://doi.org/10.1016/j.neurobiolaging.2018.06.029

 

2017

Drey, M., Hasmann, S. E., Krenovsky, J.-P. P., Hobert, M. A., Straub, S., Elshehabi, M., von Thaler, A.-K. K., Fallgatter, A. J., Eschweiler, G. W., Suenkel, U., others, Berg, D., & Maetzler, W. (2017). Associations between Early Markers of Parkinson’s Disease and Sarcopenia. Frontiers in Aging Neuroscience, 9(MAR), 53. https://doi.org/10.3389/fnagi.2017.00053

 

Hobert, M. A., Meyer, S. I., Hasmann, S. E., Metzger, F. G., Suenkel, U., Eschweiler, G. W., Berg, D., & Maetzler, W. (2017). Gait is associated with cognitive flexibility: a dual-tasking study in healthy older people. Frontiers in Aging Neuroscience, 9(MAY), 154. https://doi.org/10.3389/fnagi.2017.00154

 

Pilotto, Andrea, Heinzel, S., Suenkel, U., Lerche, S., Brockmann, K., Roeben, B., Schaeffer, E., Wurster, I., Yilmaz, R., Liepelt-Scarfone, I., others, von Thaler, A. K., Metzger, F. G., Eschweiler, G. W., Postuma, R. B., Maetzler, W., & Berg, D. (2017). Application of the movement disorder society prodromal Parkinson’s disease research criteria in 2 independent prospective cohorts. Movement Disorders, 32(7), 1025–1034. https://doi.org/10.1002/mds.27035

 

Salkovic, D., Hobert, M. A., Bellut, C., Funer, F., Renno, S., Haertner, L., Hasmann, S. E., Staebler, J., Geritz, J., Suenkel, U., others, Fallgatter, A. J., Eschweiler, G. W., Berg, D., Maetzler, W., & others. (2017). Evidence for a selectively regulated prioritization shift depending on walking situations in older adults. Frontiers in Aging Neuroscience, 9(APR), 75. https://doi.org/10.3389/fnagi.2017.00075

 

Yilmaz, Rezzak, Pilotto, A., Roeben, B., Preische, O., Suenkel, U., Heinzel, S., Metzger, F., Laske, C., Maetzler, W., & Berg, D. (2017). Structural Ultrasound of the Medial Temporal Lobe in Alzheimer’s Disease. Ultraschall in Der Medizin - European Journal of Ultrasound, 38(03), 294–300. https://doi.org/10.1055/s-0042-107150

 

2016

Lerche, S., Brockmann, K., Pilotto, A., Wurster, I., Sünkel, U., Hobert, M. A., von Thaler, A.-K., Schulte, C., Stoops, E., Vanderstichele, H., Herbst, V., Brix, B., Eschweiler, G. W., Metzger, F. G., Maetzler, W., & Berg, D. (2016). Prospective longitudinal course of cognition in older subjects with mild parkinsonian signs. Alzheimer’s Research & Therapy, 8(1), 42. https://doi.org/10.1186/s13195-016-0209-7

 

Metzger, F. G., Hobert, M. A., Ehlis, A.-C., Hasmann, S. E., Hahn, T., Eschweiler, G. W., Berg, D., Fallgatter, A. J., & Maetzler, W. (2016). Dual Tasking for the Differentiation between Depression and Mild Cognitive Impairment. Frontiers in Aging Neuroscience, 8(OCT), 1–9. https://doi.org/10.3389/fnagi.2016.00235

 

Pilotto, A, Schulte, C., Hauser, A. K., Biskup, S., Munz, M., Brockmann, K., Schaeffer, E., Synofzik, M., Maetzler, W., Suenkel, U., Srulijes, K., Gasser, T., & Berg, D. (2016). GBA-associated parkinsonism and dementia: Beyond α-synucleinopathies? European Journal of Neurology, 23(3), 520–526. https://doi.org/10.1111/ene.12894

 

Roeben, B., Maetzler, W., Vanmechelen, E., Schulte, C., Heinzel, S., Stellos, K., Godau, J., Huber, H., Brockmann, K., Wurster, I., Gaenslen, A., Grüner, E., Niebler, R., Eschweiler, G. W., & Berg, D. (2016). Association of Plasma Aβ40 Peptides, But Not Aβ42, with Coronary Artery Disease and Diabetes Mellitus. Journal of Alzheimer’s Disease, 52(1), 161–169. https://doi.org/10.3233/JAD-150575

 

Rosenbaum, D., Hagen, K., Deppermann, S., Kroczek, A. M., Haeussinger, F. B., Heinzel, S., Berg, D., Fallgatter, A. J., Metzger, F. G., & Ehlis, A.-C. (2016). State-dependent altered connectivity in late-life depression: a functional near-infrared spectroscopy study. Neurobiology of Aging, 39, 57–68. https://doi.org/10.1016/j.neurobiolaging.2015.11.022

 

Yilmaz, R, Behnke, S., Liepelt-Scarfone, I., Roeben, B., Pausch, C., Runkel, A., Heinzel, S., Niebler, R., Suenkel, U., Eschweiler, G. W., Maetzler, W., & Berg, D. (2016). Substantia nigra hyperechogenicity is related to decline in verbal memory in healthy elderly adults. European Journal of Neurology, 23(5), 973–978. https://doi.org/10.1111/ene.12974

 

Yilmaz, R., Gräber, S., Roeben, B., Suenkel, U., Thaler, A.-K. von, Heinzel, S., Metzger, F. G., Eschweiler, G. W., Maetzler, W., Berg, D., & Liepelt-Scarfone, I. (2016). Cognitive Performance Patterns in Healthy Individuals with Substantia Nigra Hyperechogenicity and Early Parkinson’s Disease. Frontiers in Aging Neuroscience, 8(NOV), 271. https://doi.org/10.3389/fnagi.2016.00271

 

2015

Hagen, K., Ehlis, A.-C., Haeussinger, F. B., Beeretz, S., Kromer, G. V., Heinzel, S., Maetzler, W., Eschweiler, G. W., Berg, D., Fallgatter, A. J., & Metzger, F. G. (2015). The relation of SMI and the VSEP in a risk sample for neurodegenerative disorders. Journal of Neural Transmission, 122(8), 1167–1174. https://doi.org/10.1007/s00702-014-1351-7

 

Heinzel, S., Metzger, F. G., Ehlis, A.-C., Korell, R., Alboji, A., Haeussinger, F. B., Wurster, I., Brockmann, K., Suenkel, U., Eschweiler, G. W., Maetzler, W., Berg, D., & Fallgatter, A. J. (2015). Age and Vascular Burden Determinants of Cortical Hemodynamics Underlying Verbal Fluency. PLOS ONE, 10(9), e0138863. https://doi.org/10.1371/journal.pone.0138863

 

Lerche, S., Brockmann, K., Wurster, I., Gaenslen, A., Roeben, B., Holz, D., Eschweiler, G. W., Maetzler, W., & Berg, D. (2015). Reasons for mild parkinsonian signs - Which constellation may indicate neurodegeneration? Parkinsonism and Related Disorders, 21(2), 126–130. https://doi.org/10.1016/j.parkreldis.2014.11.018

 

2014

Gaenslen, A., Wurster, I., Brockmann, K., Huber, H., Godau, J., Faust, B., Lerche, S., Eschweiler, G. W., Maetzler, W., & Berg, D. (2014). Prodromal features for Parkinson’s disease - baseline data from the TREND study. European Journal of Neurology, 21(5), 766–772. https://doi.org/10.1111/ene.12382

 

Heinzel, S., Liepelt-Scarfone, I., Roeben, B., Nasi-Kordhishti, I., Suenkel, U., Wurster, I., Brockmann, K., Fritsche, A., Niebler, R., Metzger, F. G., Eschweiler, G. W., Fallgatter, A. J., Maetzler, W., & Berg, D. (2014). A Neurodegenerative Vascular Burden Index and the Impact on Cognition. Frontiers in Aging Neuroscience, 6(JUL), 161. https://doi.org/10.3389/fnagi.2014.00161

 

Lerche, S., Hobert, M. A., Brockmann, K., Wurster, I., Gaenslen, A., Hasmann, S., Eschweiler, G. W., Maetzler, W., & Berg, D. (2014). Mild Parkinsonian signs in the elderly - Is there an association with PD? Crossectional findings in 992 individuals. PLoS ONE, 9(3), 1–8. https://doi.org/10.1371/journal.pone.0092878

 

2013

Heinzel, S., Metzger, F. G., Ehlis, A. C., Korell, R., Alboji, A., Haeussinger, F. B., Hagen, K., Maetzler, W., Eschweiler, G. W., Berg, D., & Fallgatter, A. J. (2013). Aging-related cortical reorganization of verbal fluency processing: A functional near-infrared spectroscopy study. Neurobiology of Aging, 34(2), 439–450. https://doi.org/10.1016/j.neurobiolaging.2012.05.021

 

2012

Berg, D. (2012). Is pre-motor diagnosis possible? – The European experience. Parkinsonism & Related Disorders, 18(SUPPL. 1), S195–S198. https://doi.org/10.1016/S1353-8020(11)70061-X

 

Berg, D., Marek, K., Ross, G. W., & Poewe, W. (2012). Defining at-risk populations for Parkinson’s disease: Lessons from ongoing studies. Movement Disorders, 27(5), 656–665. https://doi.org/10.1002/mds.24985

 

Maetzler, W., Langkamp, M., Lerche, S., Godau, J., Brockmann, K., Gaenslen, A., Huber, H., Wurster, I., Niebler, R., Eschweiler, G. W., & Berg, D. (2012). Lowered Serum Amyloid-β1-42 Autoantibodies in Individuals with Lifetime Depression. Journal of Alzheimer’s Disease, 32(1), 95–100. https://doi.org/10.3233/JAD-2012-120625

 

2011

Hobert, M. A., Niebler, R., Meyer, S. I., Brockmann, K., Becker, C., Huber, H., Gaenslen, A., Godau, J., Eschweiler, G. W., Berg, D., & Maetzler, W. (2011). Poor Trail Making Test Performance Is Directly Associated with Altered Dual Task Prioritization in the Elderly – Baseline Results from the TREND Study. PLoS ONE, 6(11), e27831. https://doi.org/10.1371/journal.pone.0027831